Cranial nerves


Cranial nerves are nerves that emerge directly from the brain in contrast to spinal nerves which emerge from segments of the spinal cord. Although thirteen cranial nerves in humans fit this description, twelve are conventionally recognized. The nerves from the third onward arise from the brain stem. Except for the tenth and the eleventh nerve, they primarily serve the motor and sensory systems of the head and neck region. However, unlike peripheral nerves which are separated to achieve segmental innervation, cranial nerves are divided to serve one or a few specific functions in wider anatomical territories.

Names of Nerves

The 12 pairs of cranial nerves are traditionally abbreviated by the corresponding Roman numerals. They are numbered according to where their nuclei lie in the brain stem, e.g. Cranial Nerve III (the Oculomotor nerve) leaves the brainstem at a higher position than Cranial nerve XII, whose origin is located more caudally (lower) than the other cranial nerves.

All cranial nerves except for the olfactory and optic nerves belong to the peripheral nervous system, having axons that are myelinated by Schwann cells (myelinating cells of the peripheral nervous system) rather than oligodendrocytes (myelinating cells of the central nervous system). The olfactory and optic nerves are named as such, but are technically not nerves, and are continuations of the central nervous system.

Note: technically the accessory nerve splits into the spinal accessory nerve and the cranial accessory nerve, but the latter quickly combines with the vagus nerve.

Cranial nerves in non-human vertebrates

Human cranial nerves are evolutionarily homologous to those found in many other vertebrates. The reptiles including birds, and mammals). Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs. These characters are synapomorphies for their respective clades. In some primitive cartilagenous fishes, such as the dogfish (Squalos acanthos), there is a terminal nerve numbered zero (as it exits the brain before the first cranial nerve).

Mnemonic devices

As the list is important to keep in mind during the examination of the nervous system, there are many mnemonic devices in circulation to help remember the names and order of the cranial nerves.

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