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The entorhinal cortex (EC) is an important memory center in the brain. The EC forms the main input to the hippocampus and is responsible for the pre-processing (familiarity) of the input signals. In the eyeblink reflex, the association of impulses from the eye and the ear occurs in the entorhinal cortex. The EC-hippocampus system plays an important role in memory consolidation and memory optimization in sleep.